Anacetrapib reveal study drug

REVEAL: Randomized EValuation of the Effects of ...

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12/3/2010 · The Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification (REVEAL) trial aims to determine whether lipid modification with anacetrapib 100mg daily reduces the risk of coronary death, myocardial infarction (MI) or coronary revascularization (collectively known as major coronary events) in patients with circulatory problems who have their Low-density Lipoprotein (LDL ...

REVEAL: Randomized EValuation of the Effects of ...

Merck & Co., Inc. - Merck Provides Update on REVEAL ...

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Merck (NYSE:MRK), known as MSD outside of the United States and Canada , today announced that the REVEAL (Randomized EValuation of the Effects of Anacetrapib through Lipid modification) outcomes study of anacetrapib met its primary endpoint, significantly reducing major coronary events (defined as the composite of coronary death, myocardial infarction, and coronary revascularization) compared ...

Merck & Co., Inc. - Merck Provides Update on REVEAL ...

Anacetrapib - Wikipedia

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In 2017 REVEAL trial anacetrapib was shown to decrease the risk of repeat heart attacks in high-risk patients with previous acute coronary events. See also. Other CETP inhibitors: Torcetrapib was developed by Pfizer until December 2006 but caused unacceptable increases in blood pressure and had net cardiovascular detriment.

Anacetrapib - Wikipedia

Randomized Evaluation of the Effects of Anacetrapib ...

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However, it is not known if these apparently favorable lipid changes translate into reductions in cardiovascular events.METHODS: The REVEAL study is a randomized, double-blind, placebo-controlled clinical trial that is assessing the efficacy and safety of adding anacetrapib to effective LDL-lowering treatment with atorvastatin for an average of ...

Randomized Evaluation of the Effects of Anacetrapib ...

Anacetrapib reduces risk of serious cardiovascular events ...

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8/29/2017 · Barcelona, Spain – 29 Aug 2017: Anacetrapib, an inhibitor of cholesteryl ester transfer protein (CETP) activity, lowers the risk of heart attack and related cardiovascular complications in patients receiving intensive statin treatment, according to late-breaking results from the REVEAL trial presented today in a Hot Line Session at ESC Congress (1) and published in the NEJM.

Anacetrapib reduces risk of serious cardiovascular events ...

Effects of Anacetrapib in Patients with Atherosclerotic ...

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Randomized Evaluation of the Effects of Anacetrapib through Lipid-modification (REVEAL) — a large-scale, randomized, placebo-controlled trial of the clinical effects of anacetrapib among people ...

Effects of Anacetrapib in Patients with Atherosclerotic ...

ACC: Merck anacetrapib reveal bodes neutral at best for ...

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3/20/2019 · The analysis, of the phase 3 REVEAL study of anacetrapib, found “no meaningful differences between characteristics between genotypes”—that is, the drug didn’t work better for people with ...

ACC: Merck anacetrapib reveal bodes neutral at best for ...

Safety of Anacetrapib in Patients with or at High Risk for ...

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In the 3 months after the 76-week treatment period, during which none of the patients were receiving the assigned study drug, there was 1 death in the anacetrapib group and there were 4 deaths in ...

Safety of Anacetrapib in Patients with or at High Risk for ...

The Effect of Anacetrapib on Vascular Function and ...

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10/12/2016 · There are currently no studies evaluating the effect of anacetrapib on blood vessel function and stiffness of the arteries. The REVEAL-Vasc trial will assess whether anacetrapib, in addition to atorvastatin (LDL-C lowering drug) treatment, results in greater endothelial-dependent vascular function and aortic stiffness in patients with established cardiovascular disease, compared to adding placebo.

The Effect of Anacetrapib on Vascular Function and ...

REVEAL: CETP Inhibitor Anacetrapib Meets Primary End Point

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The REVEAL study is a randomized, double-blind placebo-controlled phase 3 clinical trial assessing the efficacy and safety of adding anacetrapib (100 mg daily) to effective LDL-lowering treatment ...

REVEAL: CETP Inhibitor Anacetrapib Meets Primary End Point

Forget HDL, Merck Is Banking On LDL For Its Heart Drug ...

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2/5/2015 · After an 18 month, 1,623 patient phase 3 study, known as DEFINE, showed that anacetrapib was both safe and raised HDL by a remarkable 150%, Merck embarked on a …

Forget HDL, Merck Is Banking On LDL For Its Heart Drug ...

REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial

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8/29/2017 · REVEAL is by far the largest and longest trial to study a CETP, a drug class that originally raised hopes because they raise HDL levels, the so-called good cholesterol, while also lowering LDL cholesterol. CETP inhibitors can also have other off-target effects.

REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial

Merck’s Anacetrapib and REVEAL Study - marketrealist.com

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REVEAL study. REVEAL is a double-blind placebo-controlled clinical study evaluating the safety and efficacy of anacetrapib in addition to LDL-lowering treatment with atorvastatin for at least four ...

Merck’s Anacetrapib and REVEAL Study - marketrealist.com

Merck Provides Update on REVEAL Outcomes Study of ...

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6/27/2017 · The REVEAL study is a randomized, double-blind placebo-controlled clinical trial to assess the efficacy and safety of adding anacetrapib to effective LDL-lowering treatment with atorvastatin for a ...

Merck Provides Update on REVEAL Outcomes Study of ...

Comments On REVEAL, Merck's CETP Inhibitor Study

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6/28/2017 · Tuesday morning, Merck put out a press release on a clinical trial thought hopeless, the REVEAL trial.REVEAL was a multi-year study of whether a …

Comments On REVEAL, Merck's CETP Inhibitor Study

Merck's REVEAL results could spell end to CETP class ...

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8/29/2017 · Merck & Co. surprised the industry when it announced in June that its cholesteryl ester transfer protein (CETP) inhibitor anacetrapib reduced major coronary events in the REVEAL outcomes study. Yet, full data released by the big pharma on Tuesday showed the …

Merck's REVEAL results could spell end to CETP class ...

Merck Abandons Plans to Pursue Anacetrapib - Medscape

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In June, Merck announced top-line results from the phase 3 REVEAL study, the first major trial to show the cholesteryl ester transfer protein (CETP) inhibitor not only reduced cholesterol but also ...

Merck Abandons Plans to Pursue Anacetrapib - Medscape

Anacetrapib News, Research

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Anacetrapib News and Research ... levels, use of the drug evacetrapib alone or in combination with statin medications was associated with significant increases in HDL-C levels and decreases in LDL ...

Anacetrapib News, Research

Merck Announces Results of REVEAL Outcomes Study of ...

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8/29/2017 · Merck Announces Results of REVEAL Outcomes Study of Anacetrapib, Investigational Medicine for Cardiovascular Disease Results Published in The New England Journal of Medicine and Presented at the ...

Merck Announces Results of REVEAL Outcomes Study of ...

Randomized Evaluation of the Effects of Anacetrapib ...

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The REVEAL study is a randomized, double-blind, placebo-controlled clinical trial that is assessing the efficacy and safety of adding anacetrapib to effective LDL-lowering treatment with atorvastatin for an average of at least 4 years among patients with preexisting atherosclerotic vascular disease. The primary assessment is an intention-to ...

Randomized Evaluation of the Effects of Anacetrapib ...

Merck Provides Update on REVEAL Outcomes Study of ...

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KENILWORTH, N.J.--(BUSINESS WIRE)--Merck (NYSE:MRK), known as MSD outside of the United States and Canada, today announced that the REVEAL (Randomized EValuation of the Effects of Anacetrapib through Lipid modification) outcomes study of anacetrapib met its primary endpoint, significantly reducing major coronary events (defined as the composite of

Merck Provides Update on REVEAL Outcomes Study of ...

Cholesterol Drug Anacetrapib Achieves Main Goal in Late ...

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6/27/2017 · The REVEAL trial was a randomized, double-blind, placebo-controlled study to assess the efficacy and safety of adding anacetrapib to effective LDL-lowering treatment with atorvastatin for a median period of at least four years in approximately 30,000 patients at high risk of cardiovascular events.

Cholesterol Drug Anacetrapib Achieves Main Goal in Late ...

BRIEF-Merck provides update on reveal outcomes study of ...

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6/27/2017 · * Reveal outcomes study of anacetrapib met its primary endpoint * Study of anacetrapib met its primary endpoint * Plans to review results of trial with external experts, will consider whether to ...

BRIEF-Merck provides update on reveal outcomes study of ...

Shocker: Merck Cholesterol Drug Yields Benefit Where ...

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6/27/2017 · Merck announced this morning that anacetrapib, a cholesterol-lowering medicine, reduced heart problems and strokes in a 30,000-patient clinical trial, giving the …

Shocker: Merck Cholesterol Drug Yields Benefit Where ...

Anacetrapib, Merck's New Cholesterol Drug, Shows Promise ...

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11/17/2010 · Merck has a potential blockbuster in anacetrapib, an experimental cholesterol drug that dramatically increases HDL, or “good” cholesterol even as it lowers LDL, the “bad” cholesterol. But don’t hold your breath. Cardiologists, patients and investors will have to wait until at least 2015 to ...

Anacetrapib, Merck's New Cholesterol Drug, Shows Promise ...

Success for Merck’s anacetrapib | July 3, 2017 Issue - Vol ...

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7/3/2017 · In a twist for a previously troubled drug target, Merck & Co. says its CETP inhibitor anacetrapib succeeded in reducing the number of heart attacks and strokes in a large Phase III clinical trial ...

Success for Merck’s anacetrapib | July 3, 2017 Issue - Vol ...

Randomized placebo-controlled trial of anacetrapib in ...

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REVEAL: Randomized placebo-controlled trial of anacetrapib in 30,449 patients with atherosclerotic vascular disease Martin Landray and Louise Bowman on behalf of the HPS 3 / TIMI 55 - REVEAL Collaborative Group Funded by MSD, British Heart Foundation, Medical Research Council Designed, conducted and analysed independently of the funders

Randomized placebo-controlled trial of anacetrapib in ...

Anacetrapib: Hope for CETP Inhibitors? - Gurfinkel - 2011 ...

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Anacetrapib is not a potent reversible inhibitor of CYP1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, or 3A4 nor an inducer of 3A4, thereby rendering anacetrapib unlikely to cause significant drug–drug interactions .

Anacetrapib: Hope for CETP Inhibitors? - Gurfinkel - 2011 ...

Analysts, experts write off Merck's huge anacetrapib PhIII ...

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10/13/2015 · Analysts, experts write off Merck's huge anacetrapib PhIII ... on the sidelines of drug development. ... is that ACCELERATE was an underpowered study. MRK's REVEAL trial with anacetrapib is ~3X ...

Analysts, experts write off Merck's huge anacetrapib PhIII ...

Merck Reveals That Its 30,000 Patient CETP Trial Will Continue

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11/13/2015 · REVEAL is a 30,000 patient trial studying Merck’s anacetrapib. In the announcement Merck said the decision to continue the trial was based on a planned review of unblinded data by the study’s independent data monitoring committee. The review “included an assessment of futility.” Three previous CETP inhibitors have failed.

Merck Reveals That Its 30,000 Patient CETP Trial Will Continue

Anacetrapib - an overview | ScienceDirect Topics

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The ongoing Phase III REVEAL study was designed to test whether anacetrapib will reduce the incidence of major coronary events (coronary mortality, myocardial infarction, and coronary revascularization) in 30,000 patients with established CVD, undergoing statin …

Anacetrapib - an overview | ScienceDirect Topics

アナセトラピブ - Wikipedia

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第III相臨床試験(REVEAL) アナセトラピブの臨床効果を確認するため、30,000人規模の無作為化偽薬対照二重盲検試験REVEAL試験(Randomized EValuation of the Effects of Anacetrapib Through Lipid-modification)が実施されている 。

アナセトラピブ - Wikipedia

Need proof that CV outcomes are make-or-break? See Merck's ...

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6/28/2017 · See Merck's reaction to anacetrapib trial win. ... The drug met its primary endpoint in the Reveal trial, full stop. ... and the reaction to that study may be a cautionary tale for Merck with ...

Need proof that CV outcomes are make-or-break? See Merck's ...
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